Vancouver 2010 annual meeting

The 54th Annual Meeting (7th-10th July 2010) of the Society for Research into Hydrocephalus and Spina Bifida was held at the University of British Columbia, Vancouver, Canada at the invitation of the local organizing committee; Bill Arnold, Doug Cochrane, Paul Thiessen, Judi Haddy, Nicola Valentine, Bev Irwin and Carol King.

Proceedings began on Wednesday afternoon with the Annual General Meeting of Members. This was followed by a reception for all delegates and guests at the Museum of Anthropology, where we were welcomed to Vancouver by Dr. Ralph Rothstein, Acting Head of the Department of Paediatrics, Faculty of Medicine at the University of British Columbia.

The scientific programme was opened on Thursday Morning by a welcome from Dr. Ross MacGillivray, Vice-Dean of Medicine, University of British Columbia, and included sessions on 'Hydrocephalus' (Two Sessions), 'Urological Problems and Spina Bifida, 'Myelomenigocele: Management and Genetics', 'Spina Bifida: Sociological Issues', 'Choroid Plexus and Molecular Biology', 'Shunts and Infections'. This year we were pleased to have three excellent Invited Lectures, from Dr. Benjamin Warf (Bost Childrens Hospital, MA, USA), entitled 'Endoscopic Management of Children with Hydrocephalus and Spina Bifida in East Africa', from Professor Rima Rozen (McGill University, Montreal, Canada), entitled 'Biochemistry and Genetics of folate Metabolism' and from Dr. Margot Van Allen (Department of Medical Genetics, University of British Columbia, Vancouver, Canada) entitled 'Prenatal diagnosis and Folic Acid in the Detection and Prevention of Neural Tube Defects'.

The Thursday afternoon social programme consisted of a First Nations Salmon Barbeque Luncheon, a coach trip through Vancouver and a Dinner Cruise departing from Coal Harbour and sailing in Indian Arm of Burrard Inlet. The return at dusk gave the amateur photographers some spectacular views of the Vancouver Skyline in the golden light. The final event of the social programme was a gala dinner in Cecil Green House on the campus of the University of British Columbia. Click here to view photo gallery.

Meeting Programme and Abstracts

Abstract compiled by: Hugh Richards1, Deborah Sival2: Honorary Publication Secretaries 1Neurosurgery Unit, Box 167, Addenbrookes Hospital, CAMBRIDGE CB2 0QQ E-mail: hkr10@medschl.cam.ac.uk 2Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30001, 9700RB Groningen, the Netherlands E-mail: d.a.sival@bkk.umcg.nl

The full PDF file can be accessed at http://www.biomedcentral.com/content/files/pdf/1743-8454-7-S1-full.pdf

Click the title of the Paper / Poster to download the abstract

 

 

 

Wednesday 7th July 2010

08.15-13.00

 

Experimental Hydrocephalus pre-meeting discussion session.   Click here to view report

14.00

Executive Committee Meeting

17.00

Annual General Meeting (AGM) for all members

19.00

Welcome Reception: Museum of Anthropology

 

 

 

Thursday 8th July 2010

08.45

 

Introduction: Welcome  to Vancouver

09.00-10.30

 

Scientific Session 1: Urological problems and Spina Bifida

Chaired by: Deborah Sival & Sven Mattsson

09.00

Paper 1

Role of urodynamics in diagnosing tethered cord in spina bifida patients                                   

Pieter Dik, Sven Nadorp, Johan Pruijs, Rob Gooskens, Tom de Jong

09.15

Paper 2

Spinal dysraphism associated with OEIS syndrome: aspects of diagnosis and treatment               

Cora Stadtler, Reinhold Cremer, Maximilian Kellner, Thomas Boemers

09.30

Paper 3

Augmentation colocystoplasty and incontinence surgery in patients with spina bifida - our ongoing experience

Prashanth Kumar, Anant Bangar, Janani Krishnan, Santosh Karmarkar

09.45

Paper 4

Management of neurogenic bladder in myelodysplasia patients: experience at our centre

Sangram Singh, Milind Joshi, Vigya Chourishi

10.00

Paper 5

Spina bifida occulta in children: presentation and outcome

Margareta Dahl, Gunnar Ahlsten

10.15

Paper 6

Desmopressin in the treatment of nocturnal enuresis in patients with spina bifida

Pieter Dik, Paul Veenboer, Tom de Jong

10.30

 

Coffee/tea

11.00 -11.45

 

Special lecture: Dr Benjamin Warf (Boston Children's Hospital)

Hydrocephalus treatment and outcome in African infants with myelomeningocele: what we have learned so far

Introduced by Roger Bayston

 

 

11.45-12.45

 

Scientific Session 2:  Hydrocephalus

Chaired by: Ian Pople & Steve Dombrowski

11.45

Paper 7

Evaluation of prenatal diagnosis of isolated ventriculomegaly                                        

Mami Yamasaki, Masahiro Nonaka, Yohei Bamba, Chika Teramoto, Ritsuko Pooh

12.00

Paper 8

 

A Kalman filter estimation method for non-invasive measurement of intracranial pressure Kalyan

Raman, Shrihari Shridhar

CANCELLED: Replaced by Poster 12

12.15

Paper 9

Iatrogenic complications following shunting the subarachnoid space in infancy

Douglas Cochrane , Ryan Janicki, Keith Aronyk, Jeff Pugh, P Steinbok, Ash Singhal

12.30

Paper 10

Ventriculoperitoneal shunt after previous endoscopic third ventriculostomy: Does ETV improve shunt survival?

Ash Singhal , Tia Liu, Doug Cochrane, Paul Steinbok

12.45

End

 

Thursday afternoon and evening: Society Outing

 

                   Friday 9th July 2010 

08.30-10.30

 

Scientific Session 3: Myelomenigocele: Management and Genetics

Chaired by: Kathleen Sawin & Pieter Dik

08.30

Paper 11

 

Multiple surgeries in paediatric patients with myelomeningocele. Can we define quantitative and qualitative evolution patterns according to the level of spinal lesion?

Eulalia Calado, Humberto Marreiros, Clara Loff

08.45

Paper 12

Congenital myelomeningocele - do we have to change our management?

Steffi Mayer, Margit Weißer, Holger Till, Gerd Gräfe, Christian Geyer

09.00

Paper 13

Is it possible to use specific IgE to single latex allergens to discriminate between spina bifida patients with natural rubber latex allergy and sensitization?

Reinhold Cremer , Hans-Peter Rihs, Angela Gaspar, Graca Pires, Monika Raulf-Heimsoth

09.15

Paper 14

Does fetal endoscopic closure of the myelomeningocele prevent loss of neurologic function in spina bifida aperta?

R.J. Verbeek, A Heep, N Maurits, R Cremer, O Brouwer, J van der Hoeven, D Sival

09.30

Paper 15

Neuroependymal denudation is still in progress in full-term human fetal spina bifida aperta

Deborah Sival ,Montserrat Guerra, Wilfred den Dunnen, Frederico Batiz, Genaro Alvial, Esteban Rodriguez

09.45

Paper 16

Submicroscopic chromosome abnormalities associated with spina bifida (myelomeningocele)

Dan Doherty, Karen Tsuchiya, Heather Mefford, David Shurtleff

10.00

Paper 17

 

Mutations of VANGL1 in patients with neural tube defects

Valeria Capra, Patrizia De Marco, Elisa Merello, Ciprian Bosoi, Annie Reynolds, Stephanie Lanchance, Jonathan McDeramid, Philippe Gros, Gianluca Piatelli, Armando Cama, Zoha Kibar

CANCELLED: Replaced by Poster 5

10.15

Paper 18

Secondary conditions in adolescents and young adults (AYA) with spina bifida (SB) in four US programs

Timothy Brei, Kathleen Sawin, Constance Buran, Thomas Webb, Susan Cashin, Amy Heffelfinge

10.30

Coffee/tea

 

 

Session 4

Special Session: Folate and Neural Tube Defects

Chaired by: Doug Cochrane & Valeria Capra

11.00 - 11.45

 

Biochemistry and genetics of folate metabolism

Dr Rima Rozen (McGill University, Montreal)

11.45 - 12.30

 

Prenatal diagnosis and folic acid in the detection and prevention of neural tube defects

Dr Margot Van Allen (Medical Genetics, UBC)

ABSTRCT NOT AVAILABLE - see presentation in members area

12.30-12.45

 

General discussion with panel (David Shurtleff, Deborah Sival)

12.45-14.00

 

 Lunch

14.00-15.30

 

Scientific Session 5: Spina Bifida: Sociological Issues

Chaired by: Beverly Irwin & Rosemary Batchelor

14.00

Paper 19

Functional results in young adults with spina bifida. A comparative study amongst two therapeutic periods

Susana Rodriguez, Esther Pages, Ampar Cuxart, Jordi Iborra, Mar Melendez, Judith Sanchez-Raya

14.15

Paper 20

Testing a model of adaptation in adolescents and young adults (AYA) with spina bifida (SB)

Kathleen Sawin, Timothy Brei, Amy Heffelfinger, Susan Cashin, Thomas Webb, Constance Buran

14.30

Paper 21

Knowledge on and intake of folic acid supplementation in pregnant women in Denmark

Mikkel Rasmussen, Dorte Clemmensen, Claus Mosdal

14.45

Paper 22

Measuring health outcome in young adults with spina bifida

Susana Rodriguez ,Esther Pages, Ampar Cuxart, Mar Melendez, Jordi Iborra, Judith Sanchez-Raya

15.00

Paper 23

Evaluating functional and health outcomes for patients with spina bifida 5 and 10 years post-transition into adult care

Irene Chan, Doug Cochrane, Elysia Adams, Beverly Irwin, Paul Thiessen, Bonnie Sawatzky 

15.15

Paper 24

A comparison of parenting stress between mothers of children with spina bifida and able bodied controls

Lai Choo Ong, Nazli Norshireen, Vijayalakshmi Chandran

15.30

 

Coffee/tea

15.45 - 16.30

 

Session 6: Poster Viewing: moderator Hugh Richards 

 

Poster 1

Immunohistochemical study of human embryonic brain choroid plexuses and subcommissural organ

Emilia Carmona-Calero, Ibrahim Gonzalez-Marrero, Juan Gonzalez-Toledo, Agustin Castañeyra-Ruiz, Leandro Castañeyra-Ruiz, Hector de Paz-Carmona, Isabel Hernandez-Garde, Agustin Castañeyra-Perdomo

 

Poster 2

Alterations in choroid plexus gene expression in  Alzheimer's disease provide inferences for CSF composition and dynamics

Miles Miller, Edward Stopa, Elena Nkinova, Keith Tanis, Alexei Podtelezhnikov, Evan Finney, David Stone, Luiz Camargo, Lisan Parker, Ajay Verma, Andrew Baird, John Donahue, Ana Gonzalez, Brian Eliceiri, Gerald Silverberg, Petra Klinge, Conrad Johanson

 

Poster 3

Ventricular lavage for post-haemorrhagic hydrocephalus

Ian Pople, Andrew Whitelaw

 

Poster 4

Manic episode after treatment with ventriculoperitoneal shunting due to obstructive hydrocephalus with corpus callosal signal changes: a case report

Liberto Brage-Martin, Agustin Castañeyra-Perdomo, Juan C Ribas-Neijerk, Mario García-Conde, Pablo Febles-Garcia, Mario Spreafico-Guerrero, Luis Pérez-Orribo, Rebeca Pérez-Alfayate, Emilia M. Carmona-Calero, Victor García-Marín

 

Poster 5

Dysfunction of the antisiphon device, SiphonGuard, due to rupture of the shell

Kai Arnell, Pelle Nilsson

 

Poster 6

Temporary tracheostomy required as an infant may be a risk factor for future centrally mediated disordered sleep ventilation

Robert Adderley, David Wensley

 

Poster 7

Acute respiratory failure following shunt disconnection

Robert Adderley

 

Poster 8

Health Sciences Online: an extraordinary opportunity for the democratization of health sciences knowledge

Erica Frank

 

Poster 9

Patients with spina bifida and bladder cancer: Our experience

E Pages, L Montesinos, M Melendez, S Rodriguez, A Cuxart

 

Poster 10

The complex spina bifida case: a case report

Takayuki Inagaki, Tatsuo Uesaka, Sosaku Yamanouchi, Atsushi Ohashi, Keiji Kawamoto

CANCELLED

 

Poster 11

Shunting in Chronic Hydrocephalus induces VEGFR-2 and Blood Vessel Density Changes in the Caudate Nucleus

Mark Luciano, Stephen Dombrowski, Abhishek Despande, Natalie Krajcir, Jun Yang

 

Poster 12

Direct control of CSF pulsatility and its effect on CBF: Initial findings using a novel method and device

Stephen Dombrowski, Jun Yang, Serge El Khoury, Natalie Krajcir,  Mark Luciano

 

Poster 13

Defects in cell-cell junctions lead to neuroepithelial/ependymal denudation in the telencephalon of human hydrocephalic fetuses

Montserrat Guerra,  Deborah Sival, Antonio Jimenez, María Dolores Dominguez Pinos, Wilfred den Dunnen, Luis Federico Bátiz, José Manuel Pérez-Figares, Esteban Rodríguez

 

Poster 14

The disruption of the ventricular (VZ) and subventricular (SVZ) zones of the ganglionic eminences in hydrocephalic hyh mice is associated to abnormalities in the cortical GABAergic neurons

Karin Vio, Ana Ojeda, Roberto Yulis, Esteban Rodríguez

16.30-18.00

 

Scientific Session 7: Choroid Plexus and Molecular Biology

Chaired by: Conrad Johanson & Pat McAllister

16.30

Paper 25

Long-term effects of arterial hypertension on the choroid plexus, blood to cerebrospinal fluid barrier and CSF proteins and their involved in certain types of dementia

Agustin Castañeyra-Perdomo, Ibrahim Gonzalez-Marrero, Rafael Castro, Agustin Castañeyra-Ruiz, Hector de Paz-Camona, Leandro Castañeyra-Ruiz, Juan M Gonzalez-Toledo, Emilia M Carmona-Calero

16.45

Paper 26

Augurin production in the mammalian choroid plexus: Implications for CSF and hydrocephalus

Sonia Podvin, Xitong Dang, Stuart Knowling, Ana Gonzalez, Miles   Miller, Edward Stopa, Conrad Johanson, Raul Coimbra, Brian Eliceiri, Andrew Baird

17.00

Paper 27

Expression of aquaporins in a transgenic mouse model of Alzheimer's disease

Sic Chan, Meenu Madan, Srinu Chigurupati, Jogi Pattisapu

17.15

Paper 28

ECRG-4 expression in normal and neoplastic choroid plexus

John Donahue, Miles Miller, Sonia Podvin, Cynthia Jackson, Conrad Johanson, Edward Stopa, Andrew Baird

17.30

Paper 29

Acetazolamide affects aquaporin 1 expression of cultered choroid plexus cells

Jogi Pattisapu, Pouya Ameli, Meena Madan, Srinu Chigurupathi, Sic Chan 

17.45

Paper 30

Prenatal cerebrospinal fluid modulate differentiation and proliferation of rat pheochoromocytoma PC12 cells

Mohammad Nabiuni, Javad Rasouli, Kazem Parivar, Homa Kochesfhani

18.00

 

End

19.30

 

Gala Dinner: Cecil Green House

 

 

 

 

                   Saturday 10 July 2010

09.00-10.30

Scientific Session 8: Hydrocephalus

Chaired by: Roger Strachan & Michael Pollay

09.00

Paper 31

The effect of decompressive craniectomy on CSF pulsatility in experimental communicating hydrocephalus

Mark Wagshul, Shams Rashid, James McAllister, Martin Schuhmann

09.15

Paper 32

HASTE MRI in the assessment of children with hydrocephalus

Samuel Browd , Brent O'Neill, Sumit Pruthi, Harmanjeet Bains, Ryan Robison, Keiko Weir, Jeff Ojemann, Anthony Avellino, Richard Ellenbogen

09.30

Paper 33

Brain biomechanics during acute obstructive hydrocephalus in live rats

Alexander Shulyakov, Richard Buist, Stefan Cenkowski, Marc Del Bigio

09.45

Paper 34

Comparison of mild and severe forms of hydrocephalus using diffusion tensor imaging in neonatal rats

Weihong Yuan; James McAllister, Kelley Deren, Francesco Mangano

10.00

Paper 35

Definition and classification of hydrocephalus

Harold Rekate

10.15

 

Discussion on paper 35

10.30

 

Coffee

11.00-12.45

Scientific Session 9: Shunts and infections

Chaired by: Bill Arnold & Kai Arnell

11.00

Paper 36

Are adjustable valves effective in all ages of patient?  Data from the UK Shunt Registry

Hugh Richards, Helen Seeley, John Pickard

11.15

Paper 37

Complications and management of ventriculoatrial (VA) shunts, a case report

David Nash, Kevin Schmidt

11.30

Paper 38

Do Bactiseal ventriculostomy catheters have a low rate of ventriculitis and catheter colonisation in clinical practice?

Roger Strachan, Himanshu Shekhar, Shuhaib Dambatta, Pratipal Kalsi

11.45

Paper 39

A retrospective study of infections after primary VP shunt placement in the newborn with myelomeningocele without prophylactic antibiotics

D Clemmensen,  M Rasmussen, C Mosdal

12.00

Paper 40

The use of ASET (Anti Staph Epidermidis Titre) in the diagnosis of ventriculo-atrial shunt infection

Jacqueline Reaper, Sally Collins, John McMullan, Roger Bayston

12.15

Paper 41

A simple method to reduce infection of ventriculoperitoneal shunts

Tausif Rehman, Atiq-ur-Rehman, Hassaan Bashir, Vikas Gupta

12.30

Paper 42

The development of an antimicrobial EVD catheter to protect against multi-resistant hospital "superbugs"

Waheed Ashraf, Roger Bayston, Oxana Stevenson

12.45

Closing Remarks

 

Invitation to Nottingham: Roger Bayston

13.00

End

 

Multi-disciplinary membership

All international trainees, students and established professionals in any branch of research into hydrocephalus and / or spina bifida are welcome to join.